Independent · Not-for-profit · Est. 2014

Connecting the Best Data with the Brightest Research Minds.

The Corrona Research Foundation (CRF) is an independent, not for profit private foundation. The CRF has access to the deep longitudinal data on patients with rheumatoid arthritis which has been collected by more than 700 rheumatologists in 42 states. These data are derived from approximately 460,000 individual patient visits over a 25+ year span and contain the largest observational database collecting data from both physicians and patients with rheumatic diseases with simultaneous data at the time of clinical encounter.

Foundation at a glance
25+ yrslongitudinal data 26+peer-reviewed manuscripts 20+scientific abstracts 501(c)(3)non-profit
Mission

Real-world evidence that advances the standard of care.

CRF is an independent, not for profit private foundation with access to the deep longitudinal data on patients with rheumatoid arthritis collected by more than 700 rheumatologists in 42 states. These data are derived from approximately 460,000 individual patient visits over a 25+ year span — the largest observational database collecting data simultaneously from physicians and patients with rheumatic diseases at the time of clinical encounter.

About the foundation Meet the board →
What we do

Three pillars of CRF research.

From rheumatoid arthritis to psoriatic disease, CRF data powers comparative effectiveness research at the highest scientific bar.

01 Registries

Disease registries

Longitudinal observational cohorts in rheumatoid arthritis, psoriatic and spondyloarthritis — collected at the moment of clinical encounter from both physicians and patients.

Explore registries
02 Submissions

Investigator submissions

A two-step proposal process reviewed by the Board and the Clinical Investigators Committee. We support investigators with biostatistics and methodology.

How to submit
03 Publications

Publications & abstracts

Peer-reviewed work in Arthritis & Rheumatology, Annals of the Rheumatic Diseases, J. Rheumatology, and posters at ACR and EULAR annual meetings.

Browse publications
500k+
Individual patient visits captured at clinical encounter
700+
Practicing rheumatologists have contributed data
25yrs
Longitudinal observation across registry cohorts
42
U.S. states represented in the registry network
Featured publications

Findings from the registry.

View all publications
2026 · Manuscript Inflammation

TNF alpha receptor (Fn14) exacerbates TNF alpha-induced inflammation in RA synovial fibroblasts and influences response to anti-TNF alpha therapy

Shaikh FS, Shanta M, Singh AK, Daniels AM, Khuder SA, Thiele GM, Reed GW, Kremer JM, et al.

Cellular and Molecular Immunology · 2026 Jan 30

2025 · Manuscript Metabolic

Metabolic syndrome, adipokines and responses to advanced therapies in rheumatoid arthritis

Baker J, Mikuls T, Thiele G, Pappas DA, Christina-Charles C, Guma M, Harrold L, Curtis JR, Kremer JM.

Arthritis & Rheumatology · 2025; 77:263-271

2024 · Manuscript PsA

Prevalence of fibromyalgia and widespread pain in psoriatic arthritis: association with disease severity assessment in a large US registry

Mease P, Reed G, Ogdie A, Pappas DA, Kremer JM.

Arthritis Care & Research · 2024 Sep; 76(9):1313-1321

2024 · Manuscript Cardiovascular

New onset work disability in rheumatoid arthritis is an underrecognized cardiovascular risk factor: a retrospective cohort study using the CorEvitas registry

Spandorfer R, Kane K, Pappas DA, Kremer JM, Reed G, Curtis JR, Navarro-Milan I.

Seminars in Arthritis & Rheumatism · 2024; 152559

Get started

Have a research question? Bring it to the registry.

Investigators across institutions submit two-paragraph letters of intent year-round. Approved proposals advance to full review by the Clinical Investigators Committee with biostatistics support from CRF.

Start a submission Open the form